1. Human embryonic kidney cell (HEK-293)
  2. Human serum/plasma
  1. Hydrogen-Deuterium exchange pipeline [ download ]
  2. PTM-peptide enrichment pipeline
  3. Online 2D-HPLC system (SCX + RP-C18)
  4. Online low-temperature control HPLC system (pepsin + RP-C18)
  5. Peptide Mass Fingerprint (PMF): MALDI-ToF MS
  6. Tandem Mass Spectrometry (MS/MS): Orbitrap MS
  7. High-throughput IP-MS system (iMALDI-ToF MS)

Pattern Support

Publication Support

Antigenic Cross-Reactivity between SARS-CoV-2 S1-RBD and Its Receptor ACE2.

Frontiers in Immunology. 2022 in press

Yen-Chung Lai, Yu-Wei Cheng, Chiao-Hsuan Chao, Yu-Ying Chang, Chi-De Chen, Wei-Jiun Tsai, Shuying Wang, Yee-Shin Lin, Chih-Peng Chang, Woei-Jer Chuang, Li-Yin Chen, Ying-Ren Wang, Sui-Yuan Chang, Wenya Huang, Jen-Ren Wang, Chin-Kai Tseng, Chun-Kuang Lin, Yung-Chun Chuang, Trai-Ming Yeh


APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism.

 2017 Sep 6;8(1):465. doi: 10.1038/s41467-017-00493-9.

Chen, T.W., Lee, C.C., Liu, H., Wu, C.S., Pickering, C.R., Huang, P.J., Wang, J., Chang, I.Y., Yeh, Y.M., Chen, C.D., Li, H.P., Luo, J.D., Tan, B.C., Chan, T.E.H., Hsueh, C., Chu, L.J., Chen, Y.T., Zhang, B., Yang, C.Y., Wu, C.C., Hsu, C.W., See, L.C., Tang, P., Yu, J.S., Liao, W.C., Chiang, W.F., Rodriguez, H., Myers, J.N., Chang, K.P., Chang, Y.S.


In-depth proteomic analysis of six types of exudative pleural effusions for nonsmall cell lung cancer biomarker discovery.

 2015 Apr;14(4):917-32. doi: 10.1074/mcp.M114.045914. Epub 2015 Jan 31.

Liu, P.J., Chen, C.D., Wang, C.L., Wu, Y.C., Hsu, C.W., Lee, C.W., Huang, L.H., Yu, J.S., Chang, Y.S., Wu, C.C., and Yu, C.J.


Targeted proteomics pipeline reveals potential biomarkers for the diagnosis of metastatic lung cancer in pleural effusion.

 2014 Jun 6;13(6):2818-29. doi: 10.1021/pr4012377. Epub 2014 May 14.

Chen, C. D., Wang, C. L., Yu, C. J., Chien, K. Y., Chen, Y. T., Chen, M. C., Chang, Y. S., Wu, C. C., and Yu, J. S.


Comparative and targeted proteomic analyses of urinary microparticles from bladder cancer and hernia patients.

J Proteome Res. 2012 Dec 7;11(12):5611-29. doi: 10.1021/pr3008732. Epub 2012 Oct 31.

Chen, C. L., Lai, Y. F., Tang, P., Chien, K. Y., Yu, J. S., Tsai, C. H., Chen, H. W., Wu, C. C., Chung, T., Hsu, C. W., Chen, C. D., Chang, Y. S., Chang, P. L., and Chen, Y. T.


Comprehensive proteome analysis of malignant pleural effusion for lung cancer biomarker discovery by using multidimensional protein identification technology.

J Proteome Res. 2011 Oct 7;10(10):4671-82. doi: 10.1021/pr2004743. Epub 2011 Aug 24.

Yu, C. J., Wang, C. L., Wang, C. I., Chen, C. D., Dan, Y. M., Wu, C. C., Wu, Y. C., Lee, I. N., Tsai, Y. H., Chang, Y. S., and Yu, J. S.


Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas.

Mol Cell Proteomics. 2010 Jun;9(6):1100-17. doi: 10.1074/mcp.M900398-MCP200. Epub 2010 Feb 1.

Wu, C. C., Hsu, C. W., Chen, C. D., Yu, C. J., Chang, K. P., Tai, D. I., Liu, H. P., Su, W. H., Chang, Y. S., and Yu, J. S.


Discovery of novel bladder cancer biomarkers by comparative urine proteomics using iTRAQ technology.

J Proteome Res. 2010 Nov 5;9(11):5803-15. doi: 10.1021/pr100576x. Epub 2010 Sep 17.

Chen, Y. T., Chen, C. L., Chen, H. W., Chung, T., Wu, C. C., Chen, C. D., Hsu, C. W., Chen, M. C., Tsui, K. H., Chang, P. L., Chang, Y. S., and Yu, J. S.


Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance.

Proteomics. 2007 Jan;7(1):155-67.

Chen, C. D., Wang, C. S., Huang, Y. H., Chien, K. Y., Liang, Y., Chen, W. J., and Lin, K. H.